Burden of Lupus Nephritis among Patients Managed in Routine Clinical Practices in Europe
نویسنده
چکیده
Assessing the characteristics of patients with Lupus Nephritis (LN) in comparison to those without LN among patients with systemic lupus erythematosus (SLE) could help portray LN disease burden. A multi-center chart review of adult SLE patients was conducted among rheumatologists/internal medicine physicians in UK/France/Germany/Italy/Spain (EU5) to collect data on disease characteristics and treatment patterns. 168 LN patients and 569 non-LN patients with SLE were analyzed. Among LN/Non-LN cohorts, % currently receiving care in in-patient setting was:14.9/8.8, % hospitalized >=1 in the past-year was:49.4/29.7. Clinical burden (patients experiencing a flare, low C3/C4, higher SELENA-SLEDAI scores) and humanistic burden (diminished ability to perform every-day tasks, interact fully with family and friends, or work/keep employment) was higher among LN cohorts. Factors influencing the observed burden, including the therapeutic strategies used in these geographies warrant further investigation to manage LNoptimally.
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